Lyme Disease And Vitamin D
Lyme Disease And Vitamin D
Table of contents
- Lyme disease reduced Vitamin D Receptor by 8X to 50X - June 2019
- Chronic Lyme disease - Feb 2019
- Comment by the founder of VitaminDWiki
- Vitamin D Receptor category has the following
- Diseases associated with a poor Vitamin D Receptor
- Vitamin D Receptor Activators
- See also: Lyme and Vitamin D on the web
- Lyme Disease rate increased 4X in 28 years
- Lyme Disease Is Baffling, Even to Experts
- It's Time to Get Serious about Tick-Borne Diseases - Scientific American Aug 2019
Lyme disease reduced Vitamin D Receptor by 8X to 50X - June 2019
Vitamin D Receptor - activation and deactivation- self-hacked June 2019
- Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and "dead" Borrelia reduces it by 8 times 63
- This could explain why people develop autoimmune conditions after Lyme infection.
Chronic Lyme disease - Feb 2019
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Borrelia and the VDR
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.9)
Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment. Jun Sun 10)
Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is Borrelia burgdorferi. Live Borrelia burgdorferi reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates ("dead" Borrelia) reduced it by 8 times 11)
- 8) Human Tick-Borne Diseases in Australia., Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ, Front Cell Infect Microbiol9p3(2019)
- 9) Microbial manipulation of receptor crosstalk in innate immunity. Hajishengallis G, Lambris JD, Nat Rev Immunol11p187-200(2011 Mar)
- 10) Vitamin D and mucosal immune function. Sun J, Curr Opin Gastroenterolp(2010 Jul 15) Download the PDF from VitaminDWiki
- 11) Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD, PLoS Pathog5pe1000444 (2009 May) Download the PDF from VitaminDWiki
Various cancers have been documented to reduce the amount of vitamin D in the tissues (not in the blood) by deactivating the Vitamin D receptor. Lyme disease may be another disease which has learned the protection trick. A Vitamin D Receptor with poor activation is not detectable by any standard vitamin D test. Thus a person with Lyme disease could have a good blood level of vitamin D but a poor tissue level of vitamin D. There are many ways to restore the activation of the Vitamin D receptor - see below
Vitamin D Receptor category has the following
423 studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
A poor VDR is associated with the risk of 55 health problemsclick here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun, Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D in the cells |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Diseases associated with a poor Vitamin D Receptor
Increased likelihood associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
| Risk increase | Health Problem |
| 50 | Lyme Disease * |
| 28 | Leprosy - another says 3X |
| 15 | Chronic Heart Failure |
| 15 | Temporary hair loss |
| 14 | Hand, Foot, and Mouth disease |
| 13 | Sepsis |
| 11 | Metabolic Syndrome |
| 9.6 | Chronic Periodontitis and smoke |
| 8 | Juvenile Rheumatoid Arthritis |
| 7.6 | Crohn's disease |
| 7.5 | Respiratory Tract Infections |
| 5.8 | Low back pain in athletes |
| 5 | Respiratory Distress in preemies |
| 5 | Ulcerative Colitis |
| 5 | Coronary Artery Disease |
| 5 | Asthma Child see also 1.3, 2.0 and 3.6 |
| 4.6 | Breast Cancer * 16.9 X another study |
| 4.1 | Vitiligo |
| 4 | Polycystic ovary syndrome |
| 3.8 | Lupus |
| 3.6 | Pneumonia - children |
| 3.3 | Pre-term birth |
| 3.1 | Colon Cancer survival |
| 3 | Multiple Sclerosis |
| 3 | Dengue |
| 3 | Waist size |
| 3 | Ischemic Stroke |
| 3 | Alzheimer's |
| 3 | Gestational Diabetes |
| 2.9 | Hand, Foot, Mouth Disease |
| 2.8 | Osteoporosis & COPD |
| 2.7 | Gastric Cancer |
| 2.6 | Lupus in children |
| 2.5 | Lumbar Disc Degeneration |
| 2.4 | Lung Cancer |
| 2.3 | Autism |
| 2.2 | Juvenile idiopathic arthritis |
| 2.1 | Adolescent idiopathic scoliosis in Asians |
| 2 | Diabetic Retinopathy |
| 2 | Parkinson's |
| 2 | Wheezing/Asthma see also 5X |
| 2 | Melanoma Non-melanoma Skin Cancers |
| 2 | Myopia |
| 2 | Preeclampsia |
| 1.9 | Uterine Fibroids |
| 1.9 | Early tooth decay |
| 1.8 | Diabetic nephropathy |
| 1.8 | Sleep Apnea |
| 1.6 | Diabetes - Type I |
| 1.6 | Prostate Cancer while black |
| 1.5 | Diabetes -Type II |
| 1.5 | Gout |
| 1.5 | Pertussis |
| 1.5 | Obesity |
| 1.4 | Graves Disease |
| 1.4 | Rheumatoid arthritis |
| 1.3 | Childhood asthma see also 5X |
| 1.3 | Psoriasis in Caucasians |
| 1.3 | Tuberculosis |
| ?? | Rickets - Vitamin D resistant |
Vitamin D Receptor Activators
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
See also: Lyme and Vitamin D on the web
- Five Common Nutritional Deficiencies In People With Chronic Lyme Disease April 2016
- Vitamin D3, Magnesium, Zinc
- Sequel to Award-Winning Film Reveals Hope for Lyme Sufferers Mercola 2019
- Vitamin D was NOT mentioned
- What's the deal with Vitamin D? LymeMD 2008
- Appears that people trying to trat Lyme with just daily vitamin D get to toxic levels without any benefit
- No mention of the Vitamin D Receptor
"According to the U.S. Centers for Disease Control and Prevention (CDC), an estimated 329,000 Americans are diagnosed with Lyme disease each year, although some data suggest it may actually be over 444,000.1 While exact numbers are difficult to ascertain, what is known is that the prevalence is rising."
Lyme Disease rate increased 4X in 28 years
CDC
Possible reasons for increase include:
- lower D in population,
- increasing rate of poor Vitamin D Receptor,
- warmer climate
- more ticks
Lyme Disease Is Baffling, Even to Experts
Atlantic Aug 2019
Took 16 years to get her problem correctly diagnosed
- "Reported cases increased almost fivefold from 1992 to 2017, and the Centers for Disease Control and Prevention estimates that annual incidences have risen to more than 300,000, and may even range above 400,000"
- "After 40 years in the public-health spotlight, Lyme disease still can't be prevented by a vaccine; eludes reliable testing; and continues to pit patients against doctors, and researchers against one another."
- "A significant percentage of people who had Lyme symptoms and later tested positive for the disease had never gotten the rash. Others had many characteristic symptoms but tested negative for the infection, and entered treatment anyway. Most startling, a portion of patients who had been promptly and conclusively diagnosed with Lyme disease and treated with the standard course of doxycycline didn't really get better."
Lyme Disease Map 2015
It's Time to Get Serious about Tick-Borne Diseases - Scientific American Aug 2019
Scientific American Vitamin D NOT mentioned
- "Today another epidemic rages unchecked: the number of Lyme disease cases has doubled since 2004, for a total of over 400,000."
- "At least 10 to 20 percent stay sick for a year, with 5 percent still suffering 15 years later—this among patients receiving early treatment, who have the best outcomes"
- 67 Lyme Disease Clinical trials as of 2019
- "In 2017, mosquito-borne West Nile virus, which currently infects about 2,000 people annually in the U.S. received $42 million in support from the U.S. National Institutes of Health. Lyme disease, with 20 times the number of reported cases, got half as much, a figure that has changed little in a decade"
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Source: https://vitamindwiki.com/Lyme+disease+appears+to+massively+deactivate+the+Vitamin+D+Receptor+-+2019
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